
Translational Neuromodulation Group
Welcome! We are part of the Department of Neurology with Experimental Neurology at Charité Universitätsmedizin Berlin.
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Wengerlab | Translational Neuromodulation
We are interested in understanding the neural control of movement and how distortions in network communication explain motor impairment in neurological disorders. To study the underlying mechanisms, we are combining interdisciplinary methods from molecular biology, optogenetics, electrophysiology, kinematic analysis, closed-loop neuromodulation and brain-computer-interfacing. In particular, our research focuses on the development of neuroprosthetic technologies for the restoration of movement in Parkinson’s disease and stroke. We are working both in animal models and humans with the translational aim to innovate future treatments for neurological disorders.
Team members

PostDoc - Biomedical Engineering

PostDoc - Biochemistry and Optogenetics

Electronic- & Software-Engineering

PhD Student

Student Assistant

PhD Student

PhD Student

Student Assistant

Student Assistant
Former lab members
M.Sc. Naqib Rahimi, Dr.med.
M.Sc. Jonas Meyer-Ohle
Magdalena Jochner, PhD
Methods
Clinical trials
- Neuromodulation in patients with Parkinson’s disease
Experimental models:
- Parkinson models (6-OhDa)
- Stroke models (MCAo, Photothrombosis)
Experimental methods:
- kinematic analysis (DeepLabCut, Vicon)
- electrophysiology (neural recordings, EMG)
- molecular biology, optogenetics
- stereotactic surgeries
- closed-loop neuromodulation
- brain computer interfacing
News

BMBF Project STARS Kick Off
Investigation of transcutaneous spinal cord stimulation for the treatment of spasticity and gait impairment in multiple sclerosis, February 2021
(image credit to Dr. Thomas Schauer, TU Berlin)

Transregional Collaborative Research Center for Neuromodulation:
Our group is now a part of SFB/Transregio funded by the German Research Foundation (DFG), with aims to contribute to the development of innovative treatment strategies for people with currently untreatable movement disorders, May 2020

Hertie Network of Excellence in Clinical Neuroscience:
We became part of the Hertie Network of Excellence in Clinical Neuroscience, which makes us one of 6 well-established locations in Germany carrying out innovative clinical research with a strong emphasis on collaborations, November 2019

BMBF Project Mobil4Park KickOff:
Development of smart mobility assistant in patients with Parkinson’s disease
Press release, January 2019
Publications

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics
Nature protocols 13 (9), 2031 (2018)
Capogrosso M, Wagner FB, Gandar J, Moraud EM, Wenger N, Milekovic T, Shkorbatova P, Pavlova N, Musienko P, Bezard E, Bloch J, Courtine G.

Nature medicine 22 (2), 138 (2016)
Wenger N, Moraud EM, Gandar J, Musienko P, Capogrosso M, Baud L, Le Go CG, Barraud Q, Pavlova N, Dominici N, Minev IR, Asboth L, Hirsch A, Duis S, Kreider J, Mortera A, Haverbeck O, Kraus S, Schmitz F, DiGiovanna J, van den Brand R, Bloch J, Detemple P, Lacour SP, Bézard E, Micera S, Courtine G

Electronic dura mater for long-term multimodal neural interfaces
Science 347 (6218), 159-163 (2015)
Minev IR, Musienko P, Hirsch A, Barraud Q, Wenger N, Moraud EM, Gandar J, Capogrosso M, Milekovic T, Asboth L, Torres RF, Vachicouras N, Liu Q, Pavlova N, Duis S, Larmagnac A, Vörös J, Micera S, Suo Z, Courtine G, Lacour SP

Corticospinal neuroprostheses to restore locomotion after spinal cord injury
Neuroscience research 78, 21-29 (2014)
Borton D, Bonizzato M, Beauparlant J, DiGiovanna J, Moraud EM, Wenger N, Musienko P, Minev IR, Lacour SP, Millán Jdel R, Micera S, Courtine G

A computational model for epidural electrical stimulation of spinal sensorimotor circuits
Journal of Neuroscience 33 (49), 19326-19340 (2013)
Capogrosso M, Wenger N, Raspopovic S, Musienko P, Beauparlant J, Bassi Luciani L, Courtine G, Micera S
Funding
Collaborations
- PD. Dr. Nora Dengler, Dept. of Neurosurgery, Charité Universitätsmedizin Berlin
- Prof. Matthias Endres, Dept. of Neurology, Charité Universitätsmedizin Berlin
- Prof. Christoph Harms, Dept. of Neurology, Charité Universitätsmedizin Berlin
- Prof. Peter Hegemann, Humboldt University Berlin
- Prof. Andrea Kühn, Dept. of Neurology, Charité Universitätsmedizin Berlin
- Prof. Klaus Robert Müller, Technical University Berlin
- Dr. Thomas Schauer, Technical University Berlin
How to find us

Contact:
AG Wenger
Dept. of Neurology with experimental Neurology
Charité, Universitätsmedizin Berlin
Charitéplatz 1, 10117 Berlin
E-Mail: nikolaus.wenger(at)charite.de
Internal Campus Adress
Clinicial Studies
Hufelandenweg 14, AG Kühn, Floor 4
NWFZ, Neurowissenschaftliches Forschungszentrum
Experimental Neurophysiology
Virchowweg 6, Neurocure, Floor 1
CCO, Charité Cross Over Research Building
useful link:
Welcome Guide to Berlin from Schmitzlab, Neurocure