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Selected references

Mergenthaler P, Kahl A, Kamitz A, van Laak V, Stohlmann K, Thomsen S, Klawitter H, Przesdzing I, Neeb L, Freyer D, Priller J, Collins TJ, Megow D, Dirnagl U, Andrews DW, Meisel A. (2012). Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state. Proc Natl Acad Sci U S A. 109(5):1518-23.  PubMed PMID: 22233811

Isaev, N.K., Stelmashook, E.V., Lukin, S.V., Freyer, D., Mergenthaler, P.,and Zorov, D.B. (2010). Acidosis-induced zinc-dependent death of culturedcerebellar granule neurons. Cell Mol Neurobiol 30, 877-883.

Stelmashook, E.V., Lozier, E.R., Goryacheva, E.S., Mergenthaler, P., Novikova, S.V., Zorov, D.B., and Isaev, N.K. (2010). Glutamine-mediated protection from neuronal cell death depends on mitochondrial activity.
Neurosci Lett 482, 151-155.

Royl G, Balkaya M, Lehmann S, Lehnardt S, Stohlmann S, Lindauer U, Endres M, DirnaglU, Meisel A (2009). Effects of the PDE5-inhibitor vardenafil in a mouse stroke model. Brain Res. 1265:148-571 

van Zwam M, Huizinga R, Melief MJ, Wierenga-Wolf AF, van Meurs M, Voerman JS, Biber KP, Boddeke HW, Höpken UE, Meisel C, Meisel A, Bechmann I, Hintzen RQ, 't Hart BA, Amor S, Laman JD, Boven LA 2008. Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE. J Mol Med. 2008 Dec 3. [Epub ahead of print]

Klehmet J, Harms H, Richter M, Prass K, Volk HD, Dirnagl U, Meisel A*, Meisel C* (2009). Stroke-induced immunodepression and post-stroke infections: Lessons from the Preventive Antibacterial Therapy in Stroke trial. Neuroscience. 158:1184-93. 

Rückert JC, Ismail M, Swierzy M, Sobel H, Rogalla P, Meisel A, Wernecke KD, Rückert RI, Müller JM (2008). Thoracoscopic thymectomy with the da Vinci robotic system for myasthenia gravis. Ann N Y Acad Sci. 1132:329-335.

Harms H, Prass K, Meisel C, Klehmet J, Rogge W, Drenckhahn C, Göhler J, Bereswill S, Goebel U, Wernecke K, Wolf T, Arnold G, Halle E, Volk HD, Dirnagl U, Meisel A (2008). Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. PloSOne, 3(5):e2158.

Yildirim F, Gertz K, Kronenberg G, Harms C, Fink KB, Meisel A, Endres M 2008. Inhibition of histone deacetylation protects wildtype but not gelsolin-deficient mice from ischemic brain injury. Exp Neurol. 210: 531-542

Braun JS, Prass K, Dirnagl U, Meisel A, Meisel C 2007. Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH. Exp Neurol. 206:183-191.

Lehnardt S, Lehmann S, Kaul D, Tschimmel K, Hoffmann O, Cho S, Krueger C, Nitsch R, Meisel A*, Weber JR* 2007. Toll-like receptor 2 mediates CNS injury in focal cerebral ischemia. J Neuroimmunol. 190: 28-33   

Prass K, Braun JS, Dirnagl U, Meisel C, Meisel A 2006. Stroke Propagates Bacterial Aspiration to Pneumonia in a Model of Cerebral Ischemia. Stroke 37: 2607-2612.

Meisel A  Harms C, Yildirim F, Bosel J, Kronenberg G, Harms U, Fink KB, Endres M 2006. Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation. J Neurochem. 98:1019-31.

Kohler S, Wagner U, Pierer M, Kimmig S, Oppmann B, Möwes B, Jülke K, Romagnani C, Thiel A (2005). Post-thymic in vivo proliferation of naive CD4+ T cells constrains the TCR repertoire in healthy human adults. Eur J Immunol. 35:1987-94.

Meisel C, K Prass, J Braun, I Victorov, T Wolf, D Megow, E Halle, HD Volk, U Dirnagl, A Meisel 2004. Preventive antibacterial treatment improves the general medical and neurological outcome in a mouse model of stroke. Stroke. 35:2-6.

Endres M, D Biniszkiewicz, RW Sobol, C Harms, M Ahmadi, A Lipski, J Katchanov, P Mergenthaler, U Dirnagl, SH Wilson, A Meisel, R Jaenisch  2004. Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest 113: 1711-21.  

Prass K, C Meisel, C Höflich, J Braun, E Halle, T Wolf, K Ruscher, IV Victorov, J Priller, U Dirnagl, HD Volk, A Meisel 2003. Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation - reversal by post-stroke Th1-like immunostimulation. J. Exp. Med. 198: 725-736.

Prass K, A Scharff,  K Ruscher, D Löwl, C Muselmann, I Victorov, K Kapinya, U Dirnagl, A Meisel 2003. Hypoxia induced stroke tolerance in the mouse is mediated by erythropoietin. Stroke 34:1981-6.   

Ruscher K, D Freyer, M Karsch, N Isaev, D Megow, B Sawitzki, J Priller, U Dirnagl, A Meisel 2002. Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: Evidence from an in vitro model. J Neuroscience 22, 10291-301. 

Prass K, K Ruscher, M Karsch, N Isaev, D Megow, J Priller, A Scharff, U Dirnagl, A Meisel 2002. Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. J Cereb Blood Flow Metab 22, 520-525. 

Trendelenburg G, K Prass, J Priller, K Kapinya, A Polley, C Muselmann, K Ruscher, U Kannbley, AO Schmitt, S Castell, F Wiegand, A Meisel, A Rosenthal, U Dirnagl 2002. Serial analysis of gene expression identifies metallothionein II as major neuroprotective gene in mouse focal cerebral ischemia. J Neuroscience 22, 5879-5888.

Endres M*, A Meisel*, D Biniszkiewicz, S Namura, K Prass, K Ruscher, A Lipski, R Jaenisch, MA Moskowitz, U Dirnagl 2000. DNA methyltransferase contributes to delayed ischemic brain injury. J Neuroscience 20: 3175-3181

Meisel C, Meisel A. (2011). Suppressing immunosuppression after stroke. N Engl J Med. 365(22):2134-6. PubMed PMID: 22129259

Mergenthaler P, Dirnagl U. (2011). Protective conditioning of the brain: expressway or roadblock? J Physiol. 589(Pt 17):4147-55. PubMed PMID: 21708907

Kunz, A., Dirnagl, U., and Mergenthaler, P. (2010). Acute pathophysiological processes after ischaemic and traumatic brain injury. Best Pract Res Clin Anaesthesiol. 24, 495-590.

Dirnagl U, Becker K, Meisel A (2009). Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurology 8: 398-412.

Capela JP, Carmo H, Remião F, Bastos ML, Meisel A, Carvalho F 2009.Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview. Mol Neurobiol. Apr 17. [Epub ahead of print]

Kohler S, Thiel A (2009). Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets. Blood 113:769-74.

Meisel A, Meisel C (2008). Stroke-induced immunodepression: consequences, mechanisms and therapeutic implications. Future Neurology 3, 551-563.

Dirnagl U, Meisel A. (2008). Endogenous neuroprotection: Mitochondria as gateways to cerebral preconditioning? Neuropharmacology. 334-344. 

Dirnagl U, Klehmet J, Braun JS, Harms H, Meisel C, Ziemssen T, Prass K, Meisel A (2007). Stroke-induced immunodepression: experimental evidence and clinical relevance. Stroke 38:770-773.   

Meisel C, Schwab JM, Prass K, Meisel A, U Dirnagl (2005). Central nervous system injury-induced immune deficiency syndrome. Nature Reviews Neuroscience 6: 775-786.     

Mergenthaler P, U Dirnagl, A Meisel 2004. Pathophysiology of stroke: lessons from animal models. Metab Brain Dis 19: 151-167

Harms H, K Prass, U Dirnagl, A Meisel 2004. Therapierelevante Pathophysiologie des akuten ischämischen Schlaganfalls: Was ist gesichert? Akt Neurologie. 31, 113-121.