Translational Neuromodulation

Welcome! We are part of the Department of Neurology with experimental Neurology at Charité Universtiy Medicine Berlin.

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Wengerlab | Translational Neuromodulation

We are interested in understanding the neural control of movement and how distortions in network communication explain motor impairment in neurological disorders. To study the underlying mechanisms, we are combining interdisciplinary methods from molecular biology, optogenetics, electrophysiology, kinematic analysis, closed-loop neuromodulation and brain-computer-interfacing. In particular, our research focuses on the development of neuroprosthetic technologies for the restoration of movement in Parkinson’s disease and stroke. We are working both in animal models and humans with the translational aim to innovate future treatments for neurological disorders.

Methods

Clinical trials
- Neuromodulation in patients with Parkinson’s disease

Experimental models:
- Parkinson models (6-OhDa)
- Stroke models (MCAo, Photothrombosis)

Experimental methods:
- kinematic analysis
- electrophysiology (neural recordings, EMG)
- molecular biology, optogenetics
- stereotactic surgeries
- closed-loop neuromodulation
- brain computer interfacing

Team members

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MD PhD Nikolaus Wenger

Group Leader - Translational Neuromodulation

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Christina Salchow-Hömmen, MSc

Research Associate Scientific Coordinator Clinical Studies und Mitarbeiterin AG Kühn

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Magdalena Jochner, PhD

Research Associate Mobil4Park Project und Mitarbeiterin AG Kühn

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Arend Vogt, PhD

Biochemistry and Optogenetics

News

BMBF Project Mobil4Park KickOff:

Development of smart mobility assistant in patients with Parkinson’s disease
Press release January 2019

Award ceremony:

Dr. Nikolaus Wenger is awarded Freigeist Fellowship from Volkswagenstiftung
Germany press release, September 2018

Dr. Nikolaus Wenger receives GSK Research Award for the development of spatiotemporal neuromodulation strategies for the treatment of neuromotor impairment
press release, July 2017

Publication

Conguration of electrical spinal cord stimulation through real-time processing of gait kinematics

Nature protocols 13 (9), 2031 (2018)

Capogrosso M, Wagner FB, Gandar J, Moraud EM, Wenger N, Milekovic T, Shkorbatova P, Pavlova N, Musienko P, Bezard E, Bloch J, Courtine G.

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Journal of neural engineering 15 (2), 026024 (2018)

Capogrosso M, Gandar J, Greiner N, Moraud EM, Wenger N, Shkorbatova P, Musienko P, Minev I, Lacour S, Courtine G

Mechanisms Underlying the Neuromodulation of Spinal Circuits for Correcting Gait and Balance Decits after Spinal Cord Injury

Neuron 89 (4), 814-828 (2016)

Moraud EM, Capogrosso M, Formento E, Wenger N, DiGiovanna J, Courtine G, Micera S

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Nature medicine 22 (2), 138 (2016)

Wenger N, Moraud EM, Gandar J, Musienko P, Capogrosso M, Baud L, Le Go CG, Barraud Q, Pavlova N, Dominici N, Minev IR, Asboth L, Hirsch A, Duis S, Kreider J, Mortera A, Haverbeck O, Kraus S, Schmitz F, DiGiovanna J, van den Brand R, Bloch J, Detemple P, Lacour SP, Bézard E, Micera S, Courtine G

Electronic dura mater for long-term multimodal neural interfaces

Science 347 (6218), 159-163 (2015)

Minev IR, Musienko P, Hirsch A, Barraud Q, Wenger N, Moraud EM, Gandar J, Capogrosso M, Milekovic T, Asboth L, Torres RF, Vachicouras N, Liu Q, Pavlova N, Duis S, Larmagnac A, Vörös J, Micera S, Suo Z, Courtine G, Lacour SP

Closed-loop neuromodulation of spinal sensorimotor circuits controls rened locomotion after complete spinal cord injury

Science translational medicine 6 (255), 255ra133-255ra133 (2014)

Wenger N, Moraud EM, Raspopovic S, Bonizzato M, DiGiovanna J, Musienko P, Morari M, Micera S, Courtine G

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

Neuroscience research 78, 21-29 (2014)

Borton D, Bonizzato M, Beauparlant J, DiGiovanna J, Moraud EM, Wenger N, Musienko P, Minev IR, Lacour SP, Millán Jdel R, Micera S, Courtine G

A computational model for epidural electrical stimulation of spinal sensorimotor circuits

Journal of Neuroscience 33 (49), 19326-19340 (2013)

Capogrosso M, Wenger N, Raspopovic S, Musienko P, Beauparlant J, Bassi Luciani L, Courtine G, Micera S

DLK1(PREF1) is a negative regulator of adipogenesis in CD105+/CD90+/CD34+/CD31-/FABP4- adipose-derived stromal cells from subcutaneous abdominal fat pats of adult women

Stem Cell Research 9 (1), 35-48 (2012)

Mitterberger MC, Lechner S, Mattesich M, Kaiser A, Probst D, Wenger N, Pierer G, Zwerschke W

How to find us

Contact:

AG Wenger
Dept. of Neurology with experimental Neurology
Charité, University Medicine Berlin
Charitéplatz 1, 10117 Berlin

E-Mail: nikolaus.wenger(at)charite.de

Internal Campus Adress

Clinicial Studies
Hufelandenweg 14, AG Kühn, Floor 4
NWFZ, Neurowissenschaftliches Forschungszentrum

Experimental Neurophysiology
Virchowweg 6, Neurocure, Floor 1
CCO, Charité Cross Over Research Building