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During the course participants will be exposed to all relevant in vivo or in vitro experimental models in cerebral ischemia and stroke research. A major focus lies on the understanding of the differential validity and limitations of the various models and their outcome parameters. In addition, all models will be discussed in the context of their clinical relevance. Special emphasis will be put on quality issues, including standard operating procedures. The most relevant models will be demonstrated by experienced faculty members, however, hands on exercises by the participants are not possible due to legal as well as practical issues.